StackTerminal.Health

BETA

Ashwagandha

Adaptogen with consistent evidence for stress, cortisol, & testosterone support; one of the best-evidenced adaptogens.

stressrecoveryhormonessleepstrength
Evidence last reviewed: 04 Apr 2026
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Trade-offs & context
Known concerns, timing considerations, & interactions
Interaction

May elevate thyroid hormones (T3/T4) — caution with thyroid conditions or thyroid medications

Liver

Rare hepatotoxicity cases reported — discontinue if liver enzymes elevated; likely dose- or contaminant-related

Interaction

May potentiate sedatives and anxiolytics — additive CNS depression

Dot colour: High concern  Moderate   Low / note
Biomarkers studied
Outcomes directly measured across the evidence records below
Sleep
Sleep Quality (subjective)Sleep Latency
Cardiovascular
VO₂ Max
Cognitive
Anxiety
Performance
Muscle Strength (1RM)
Evidence
3 records
Physical performance (strength, VO2max)
Healthy adults and athletesSystematic review & Bayesian meta-analysis
PUBMEDModerate

Significant improvements in muscle strength, power, & VO2max compared to placebo across 13 RCTs.

Dose: 600 mgDuration: 8–12 weeks
Effect sizes moderate; responder variability exists.
Sleep quality / sleep onset latency
Adults with and without insomniaSystematic review & meta-analysis (5 RCTs, n=400)
PUBMEDModerate

Small but significant improvement in overall sleep (SMD −0.59); stronger effects in insomnia subgroup & at ≥600 mg/day for ≥8 weeks.

Dose: 600 mgDuration: 8–10 weeks
No serious adverse effects reported in included trials.
Perceived stress & anxiety reduction
Adults with insomnia and anxietyRCT (double-blind, placebo-controlled)
PUBMEDModerate

300 mg ashwagandha root extract twice daily significantly improved sleep quality, anxiety scores, & mental alertness on rising vs. placebo.

Dose: 300 mgDuration: 10 weeksForm: root extract
Dose refers to standardized KSM-66 extract. Stress & anxiety benefits seen across multiple RCTs.
Forms
KSM-66 (root extract)
Most trialled form; 5–10% withanolides.
Sensoril (leaf + root)
Higher withanolide content; more sedating.

Stacks containing Ashwagandha

Public community stacks that include this ingredient.

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womens-healthconstraints

My Sample Stack

by@tin_man140_6

Built from your selected goals, constraints, diet, & the supplement evidence library. You can edit doses & timing.

Vitamin B-Complex
26mg
Vitamin C
500mg
Ashwagandha
600mg
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stressmoodanxiety

Combining Rhodiola Rosea with Ashwagandha can reduce stress and enhance mood. Rhodiola is an adaptogen that helps manage stress, while Ashwagandha is known for its mood-enhancing and stress-reducing properties.

Rhodiola Rosea
200mg
Ashwagandha
300mg
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mens-healthfertilitytestosterone

Male factor infertility accounts for ~50% of cases & is largely driven by oxidative stress, micronutrient deficiency, & suboptimal testosterone. Ashwagandha has RCT evidence for significantly improving sperm concentration, motility, & testosterone. L-carnitine is the most evidence-backed intervention for sperm motility. CoQ10 & selenium reduce seminal oxidative damage, while zinc is essential for spermatogenesis & androgen synthesis.

Ashwagandha
600mg
L-Carnitine / Acetyl-L-Carnitine (ALCAR)
2000mg
Coenzyme Q10
300mg
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stressmoodcalm

Ashwagandha & lemon balm are combined to support stress reduction & enhance mood. Ashwagandha is an adaptogen that reduces stress & anxiety, while lemon balm provides calming effects & improves mood.

Ashwagandha
300mg
Lemon Balm
600mg
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recoverysleepfocus

Supports training consistency under physical & mental stress.

Ashwagandha
600mg
Glycine
3000mg
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